• Are we taking supercomputing code seriously?
• Odds Are, It’s Wrong: Science fails to face the shortcomings of statistics
• A survey of cross-validation procedures for model selection

class redict(dict):
    def __init__(self, d):
        dict.__init__(self, d)

    def __getitem__(self, regex):
        r = re.compile(regex)
        mkeys = filter(r.match, self.keys())
        for i in mkeys:
                yield dict.__getitem__(self, i)

With this you can do the following:

>>> keys = ["a", "b", "c", "ab", "ce", "de"]
>>> vals = range(0,len(keys))
>>> red = redict(zip(keys, vals))
>>> for i in red[r"^.e$"]:
...     print i
...
5
4
>>>

After having seen some more InChI related things atthe BioIT World yesterday, I thought I’d have another go at some InChI stuff. And I was again quite surprised to what I found, and actually even more confused.

Here’s what I did:

I took two molecules from PubChem (diaisostereomers) cis- and trans-1,2-dihydroxy-cyclohexane (1,2-cyclohexanediol). I created InChIKeys for both of them, using different inputs. And not at all did I end up with two different InChIs for these two structures that were the same.

The SMILES and InChIKey from PubChem are the following:
cis-1,2-cyclohexanediol: C1CC[C@@H]([C@@H](C1)O)O - PFURGBBHAOXLIO-OLQVQODUSA-N
trans-1,2-cyclohexanediol: C1CC[C@H]([C@@H](C1)O)O - PFURGBBHAOXLIO-PHDIDXHHSA-N

I used the Standard InChI generator v1.2 released in January 2009 by the IUPAC, more specifically the Linux binary. Because this software doesn’t read SMILES, one has to convert the SMILES input molecules to SD files. This was done with OpenBabel and Pipeline Pilot. In addition, I used CML obtained from OpenBabel as input, too.

And here is what I obtained:

Now, this raises the following questions:

1. First of all, why do I not just get the same InChI for everything? Isn’t it supposed to canonicalize the structure to a fair extent (I know it does) and come up with the same InChI?
2. If there are different ways of getting a presumably valid InChI for a compound, which one should one take?
3. Why do I get the same InChI for different stereoisomers when the 3D coordinates come from OpenBabel, but not if the coordinates come from Pipeline Pilot? Is the 3D coordinate generation in OpenBabel the problem?
4. Why do I get the correst stereoinformation in the InChIKey when I use CML without any coordinates?
5. Why do I get a different hash for the connectivity part when I use CML without any coordinates? FWITZFBVZWAIRX instead of PFURGBBHAOXLIO?
6. And then, if CML without 3D coordinates gives the right stereochemistry in the InChI, why doesn’t 3D CML with coordinates from OpenBabel?
7. 3D CML from PipelinePilot coordinates also doesn’t get the stereochemistry part right; instead, there’s yet a different connectivity part DQQAEJAQEMHJBB.
8. Why should the stereochemistry come out right when 2D coordinates are used, but not if 0D coordinates are used?
9. Why not get InChIs directly from SMILES?

Any comments on this anybody? I seriously wonder.

The city is divided into two general regions: the Ephesus old city spreading down from the Citadel, with Selcuk Square as its center; and “Ephesus 13th century BC the Greek peninsula was invaded by the Dorians” with Ayasuluk center about a mile from Selcuk in Ephesus Tours Guide you should know that some buses are privately owned.

Also, For these, you can purchase a ticket right on the bus, for slightly less than the cost of a city bus ride fom Kusadasi Port or the ephesus tours from izmir kusadasi and istanbul.

Connecting Izmir and Ephesus is Atatürk Bulvar?, the city’s main thoroughfare and reference point for all your wanderings in the city.

The local Tourism Information Office is in the headquarters of the Ministry of Tourism, Gazi Mustafa Kemal Bulvar? no. 33 (beginning in Kusadsi), in the section called Demirtepe. ( Best time to visiting Ephesus is April, May, September October.)

You can walk there in about ten minutes from Selcuk. Head west out of the square, and make sure that you’re on the left (southern) side of the street Cave of the Seven Sleepers, because soon there will be a barrier down the middle of the street, and you won’t be able to cross; you’ll have to walk about half a mile out of your way just to get across the street! The lettering over the door of the Ministry reads “Kültür ve Turizm Bakanl??i”. The actual Tourism Information Office is around to the right side, on Ephesus. There are also small Tourism Information ( see: http://www.ephesustoursguide.com/ ) desks at the Ephesus airport.

Selcuk square is a vivid demonstration of lesser economics. Every conceivable product and service is offered here; nothing that will provide an honest (or sometimes otherwise) living is left out. On the sidewalk, of private tours to Ephesus with a big new department store as a backdrop, a man washes his hands while speaking into a microphone, plugging the brand of soap he is demonstrating.

The Artemis Temple and around shoeshine boys are everywhere and have boxes every inch as elaborate as those in Ephesus- Basilica of St. John and Museum of Ephesus, some even including such gadgets as electric bells (to attract the attention of would-be customers), portable radios (for music to work by), and tiny lamps directed at the work area (for working at night). Elsewhere, an old man in a gay knit cap is manning an ancient doctor’s scale, by means of which he’ll determine your weight in kilograms for a charge of 100TL (140).

Men dressed in white circulate through the crowd pushing carts filled with flaky, pastry like börek. A battered old station wagon has been parked on the sidewalk, its tailgate let down to display an assortment of men’s shirts which the driver-proprietor is offering for sale at bargain rates. In the midst of the loudspeaker spiels by countless hawkers, one old man sits quietly and contentedly on a stool with a box of metal shoe cleats and a ganglion of laces before him. You don’t even have to remove your shoes in order to have him tap a cleat on with his little hammer. department store is filled with row upon row of jars filled with golden honey which light up when the sun catches them.

The hills east of Ephesus have been inhabited by Christian ascetics since the 400s. Within a century after the first monks arrived, Jacob Baradeus, bishop of Edessa (now the Turkish city of Izmir), got into a bitter theological wrangle with the bishop of Constantinople. The controversy, over the exact nature of the divinity of Christ, turned on this point: did Christ have both a divine and a human nature, as the bishop of Constantinople held, or did he have only a di Ephesus vine nature, as Baradeus said?

Constantinople was more powerful than Ephesus Tours for Cruise Customers dessa, and Baradeus lost the argument, so he promptly set up his own church based on the single-nature (Temple of Artemis) beliefs. His followers were known as Jacobites, and many of them fled the control of Constantinople to settle in these barren hills. Today their descendants are known as the Syrian Orthodox church.

The monastery is still inhabited and working, now mostly Ephesus Tours as an orphanage for a handful of local lads. The Selcuk patriarch’s suite of rooms is kept in readi Ephesus for a visit, though he has not dropped by for decades.

The monastery was founded on this spot in 792. As you enter beneath a plaque bearing an inscription in Selcuk, a black-robed, bushy-bearded priest will greet you, then call one of the orphan boys to give you the standard tour, which includes a took at an extremely ancient underground room with a stone ceiling. It may have been used first by Artemis. Also on the tour is a look at the tombs of the various prelates who have headed the monastery through the Ephesus.

Private Ephesus Tours Turkey, more commonly called from Izmir to Ephesus , was once called Edessa. It got that name from Alexander the Great, who granted it in honor of a fondly remem Ephess bered town in his native Macedonia. That was several centuries before Christ, but Alexander’s town was not the first one on the site.

Most of the Ephesus Christians hereabouts are in or near Izmir, which at one time was the official seat of the bishop of Selcuk, otherwise known as the Ephesus Orthodox patriarch.

The earliest settlement here may date as far back as 1500 B.C., when some people set up camp, perhaps in a cave. The Babylonians called them Hurri, a name which has its root in the Babylonian word for cave. Well, there is still a cave here, and it’s now revered as the birthplace of Abraham, so we may have a history of occupation and reverence spanning 3,500 years. The Hurrites knew about chariots, the technological miracle of the age, and they used these versa Ephesus tile weapons to build a great empire with this city as its capital. Ever since then Urfa has been the most important town in the region, and often the seat of kings, princes, and bishops.

After the Hurrites came the Hittites, whose real power center was nearby Carcemish (of which little remains). Assyrians took over from the Hittites, and then Alexander took over from them. After Alexander, his successors, the Se-leucids, gained control, but they were superceded by the Aramean people who held onto Edessa, just barely, until the coming of the Romans some four centur Ephesusies later. The Arameans spoke Aramaic, the language of Jesus, which is interest Ephesusing to note because the Edessans adopted Christianity around the year 200, before just about everyone else. Some historians think they did this because they liked being contrary, a people apart, not subject to control from outside. The Edessans naturally used Aramaic in their services, and the Syrian Ortho Ephesusdox church (the modem continuation of the ancient Edessan church) still uses the language of Jesus in its services today.

Walking is the best way to see Ephesus, as all of its significant buildings are up or down the steep hillside off Terrace Houses. Actually, walking is the only way to see the sights. In summer, walking here is very hot work, you can see the ephesus tours at the Kusadasi Town.

Walk east from Selcuk Meydan? to the Ephesus on the left-hand side. Turn left (north) up the Basilica St.John and Temple of Artemis. Its magnificent doorway is the building’s prime feature; there is little to see on the inside, which is a private residence in any case.

To the left of the doorway, in a building adjoining the medrese, is the small, quaint Ephesus Museum. Look for the flagpole and sign. You may have to make some noise to rouse the attendant, who will let you in for free anytime between 8:30 a.m. and 5:30 p.m. daily if he’s around.

Ephesus’s Arab-style Great Mosque (Isabey Mosque) was built by Seljuk Turks from Iraq in the 1000s. The stone building withstood the tumult of centuries pretty well until, in 1832, during a Kurdish rebellion, it was blown up. Some of it has been rebuilt. Look for it just down the slope from Cumhuriyet Meydan?.

Ask for directions as there are no signs if your ephesus private day tours to be great. The high point of the ephesus private tours is a visit to the small, quaint but harmonious chapel, with a throne for the patriarch, another for the reigning metropolitan (bishop), a carved stone altar, and many charming primitive paintings and woven pieces.

At the end of the tour, the guide will refuse your tip once or twice (offer about $5), but custom demands that you persist. Finally he’ll accept.

Of the Aamazones monasteries in this region, the most accessible is that of Temple of Artemis build VII Century B. C. “one of the Seven Wonders”

What tourism can mean for the country in terms of foreign credit and cultural exchange, and has therefore entrusted the promotion of tourism to a ministry formed expressly for this purpose. Ephesus, Istanbul and Cappadocia is mean of tourism in Turkey.

The work of restoring historical sites, encouraging the construc tion of new tourist facilities, supervising hotel and restaurant policies and the like has been going on for several years with gratifying results. At Ephesus Tours almost every area of Ephesus interest to tourists can boast of some advance within the last few years. And yet Biblical Tours inTurkey is not in the company of slick attractions where prices are high and things are just like home, with none of the flavor of another country or cul ture.

It still has that “edge” that keeps it in the realm of the “unspoiled” places, where the excitement of discovery has not been whittled away by too much pro motion and commerciality Seven Churches in Turkey.

Right now, in all of the places that you’ll want to visit in Ephesus:

• Ephesus
• Ephesus Terrace (Slope) Houses
• House of the Virgin Mary
• Basilica St.John
• Temple of Artemis
• Seven Sleepers
• Sirince Village
• Kusadasi
• Izmir

The ephesus private tours operates in that one can travel in Ephesus spending $ 125 a day for lodging and three meals, broken down so that approximately $83 is for atour.

Transporta tion, entertainment, sightseeing, and shopping in Ephesus are not included in this basic budget. Spending $65 a day. Ephesus tours enables one to stay in clean, comfortable, safe suitable for people of all ages and both sexes.

For younger, more impecunious travelers, less expensive tours, and offering less comfortable at rock-bottom prices have been included. And for those with a little extra money to spend, there are a number of private tours.

When l first arrived in Turkey, flying into the airport in Izmir, I confirmed my vague suspicions that Turkey was a hot, dusty desert of low rolling hills and sparse, scrubby vegetation. But when I got on the ground and traveled around a bit, I discovered that this relatively big country, has craggy, snow capped mountains, broad lakes, cool pine forests, miles of white beaches, snowy winters, long summers a lot to offer a tourist.

At the end of summer on the Anatolian plateau, after months of straight sunshine, the land is dry and dusty. When I flew into Ankara I didn’t notice that the city was pretty well deserted. Why stay in the city when there are so many nicer places to be? The Black Sea coast is relatively close and the Sea of Marmara and the beaches of the Aegean a day’s bus or train ride, to Ephesus. Izmir’s people seek out the good places and wait until the city is pleasant again.

The Istanbullus leave their city for villas and cabins on the shores of the Bosphorus or for hotels and resorts on the nearby Princes’ Islands in the Sea of Marmara. As the season passes and the weather cools, the places to prolong outdoor activities are the numerous spas and hot springs, especially those at Pamukkale (the old Greco-Roman spa of Hierapolis), where one can stay in a modern resort hotel for $20 double and swim in its pool of warm mineral water strewn with columns and other artifacts from the ancient past. Before getting to izmir for private ephesus tours we decide to take a trip to Manisa, we was so excited to see Ephesus and the House of Virgin Mary in Izmir. (see: Ephesus Tours Videos).

Turkey is a country of subtle beauties. An early-morning scene on the Ana tolian plateau: a mesa in the distance with a nomad’s tent at the base, his horse quietly grazing in the dewy grass as the sun creeps across the plain; the incredi ble blue color of the Aegean Sea; a caravan of gypsies in their picturesque wag ons passing a moonscape of rock pinnacles once hollowed out and inhabited by early Christians; the palm trees lining the waterfront in Izmir moving gently in the wind, the whole town dominated by a citadel dating from the time of Alex ander the Great; the sun setting into the Golden Horn of Istanbul, seeming to turn the water to gold and thus giving the river its name. Add to these the stories of a dozen civilizations, each of which has helped form the Turkey of today, and you have a place to compel your imagination and hold your interest for quite a while especially Istanbul.

Turkey holiday and travel, istanbul tours, is the city of the former Caliphate of Islam and of the Ecumenical Patriarchate of the Orthodox Church, of Turkish mosques and Byzantine churches. In the museums are beautiful Christian mosaics and ancient Turkish miniatures. The effect on a visitor is an instant fascination with the Oriental fac ets of the city and a comfortable familiarity with the Occidental. After a morn ing spent in the sultan’s Seraglio, there’s a lunchof wienerschnitzel and beer; or, conversely, a day in Istanbul’s European quarter and a dinner of shish kebap and rak?. The city harbors an amazing variety of peoples even today, and each holds to its ancient traditions and way of life. On the Golden Horn, children crowd to Greek schools in the section called Fener. In Galata there are two syn agogues, attended by people whose ancient forebears were driven from Spain by the Inquisition and who even today speak a dialect of Spanish. In the section called Beyo?lu, once the old city of Pera, little carpenters’ and tailors’ shops, restaurants, and coffeehouses bear Russian, Italian, German, French, and Bal kan names. Near the Bosphorus in Asia is a Polish village where the best pork products in Turkey are made. And over all these different flavors added by mi norities is the Turkish culture, its great mosques, delicate faience, Turkish De light, and tradition of the romance of the East.

The sun sets in ?zmir, poised between the twin mountain peaks that domi nate the harbor, said to be the place where the goddess Nemesis lived ; the call to prayer drifts up from the minarets in the city of Bursa to the slopes of the Asian Mount Olympus, now Turkey’s most popular ski resort; in the fast-growing va cation town of Ephesus Ku?adas? on the Aegean coast a Turk sits in his coffeehouse, drinking Turkish coffee and smoking a bubbling narghile; a modern cruise ship steams toward the ancient cities of Tarsus and Antioch, the sun rising on its bow. Ephesus and the Cappadocia is what Turkey holds for the visitor today, and all of it at prices that equal or beat the lowest in Europe.

Hatay sat?l?k evleri, geni? ödeme seçenekleri ile sizleri geni? bir ev sahibi yapmay? amaçlamaktad?r. Hatay sat?l?k 3+1 evler veya Hatay sat?l?k 4+1 evler sayfalar?ndaki ilanlardan birisine sahip olarak e?yalar?n?z? evinize uyarlamak yerine, evinizi e?yalar?n?za göre seçebileceksiniz. Her say?da aileye yetebilecek kapasitedeki bu evler, oda say?s?n?n büyüklü?ü ile beraber, odalar?n büyük olmas? ile de büyük avantajlar sa?lamaktad?r. Hatay sat?l?k evler opsiyonlar?nin yerden ?s?tmal? sistemi sayesinde, evin her kö?esinde bulundu?unuzda s?cakl??? ayn? derecede hissedebilecek, k??lar?n?z? s?cak bir ortamda geçirebileceksiniz.

Hatay sat?l?k 3+1 evlerinin büyüklü?ü 125 metre kare olup, bir adet balkonu bulunmaktad?r. Hemen hemen her katta bu evlerden bulunmaktad?r. Ço?u s?f?r olan bu evlerin ilk kullan?c?s? siz olabilirsiniz. Ayn? ?ekilde Hatay sat?l?k 4+1 evlerinin de birço?u s?f?r evlerdir. 145 metre kareye sahip bu evlerde rahat bir ya?am sürebileceksiniz. Elinizi h?zl? tutarak, evin ilk kullan?c?s? olarak, evinizi kendi diledi?iniz ?ekilde kullanabileceksiniz. Özenle yap?lm?? ve dü?ünülmü? mutfak dolaplar?, ayn? ?ekilde kullan??l?l?k aç?s?ndan da büyük titizlikle tasarlanm??t?r.

If you are working on some project or assignment and for that you have to convert various different units for your convenience then the best thing is that you should find an online converter. For example if you have to convert acceleration units in any other format then you can do that online. Same you can convert mass units to other forms also.

You can search different web sites online that are providing you such services where you can also do angle unit conversion, all this will be beneficial for you when you are doing some construction work or another related assignment.